Miesiąc: Grudzień 2019

Traveling with CBD – Baltimore Post-Examiner

Of course, when we talk about rest and relaxation, products like CBD gummies for anxiety come to mind just as much as the thought of being on a long vacation away from the hustle and bustle of daily life.  So, it’s no surprise that most vacation-goers are wondering how they can properly bring CBD with them onto a plane.

For those looking to travel with CBD this new year, this guide is for you.  We’ll be covering your questions regarding if and how you can travel with CBD, plus dive into different tips so that your trip can be as seamless as possible.  After all, the last thing you want happening is having your CBD confiscated before boarding.

Can You Travel with CBD, According to the TSA?

Now, here’s the thing about CBD – the rules and laws regarding it are always changing.  That’s because CBD is such a new industry that a lot of lawmakers don’t quite know what to do with it.  As of now, CBD is legal on a federal level, which means that it can be bought and used without any problems.  But the TSA is a bit behind the times, as they still believe that hemp and marijuana are the same thing, despite scientific evidence that states otherwise.

As you know, CBD can come from either the hemp plant or the marijuana plant.  Only CBD that comes from the hemp plant is legal, because hemp only has 0.3 percent THC, which is the psychoactive ingredient that is far more abundant in marijuana.  However, the TSA doesn’t seem to make this distinction, viewing all cannabis products as against their rules.

So, does that mean that having CBD in your luggage will get you arrested?  Well, not exactly.  The TSA just doesn’t really care all that much about substances that they deem restricted, believe it or not.  And, there’s a really good reason for that.  The TSA’s job is to keep you safe, not get you arrested.  So, what they’re looking for is weapons.  And, they don’t have a lot of time, since those security lines are so long.  So, they’re not really inspecting every substance that you bring, but, rather, looking for dangerous objects that can harm others.

How to Bring CBD with You During Your Travels

Now that you understand when it comes to safely bringing CBD on a plane and likely get through without any problems.  Still, some agents remain harsher than others, so follow these tips below to make sure that you don’t get your CBD taken away.

Tip #1: Follow the TSA’s Guidelines Carefully and Thoroughly

Since 9/11, the TSA’s rules about how you can pack your items became far stricter.  Of course, this is to keep us safe.  And, it means that you have to abide by their rules, or else you may not be allowed on a plane, and they make take your items away from you.  So, treat CBD like you would any other product that you pack, and store it according to the guidelines posted on the TSA’s website.

Tip #2: Bring Paperwork Just in Case

If you end up with a particularly suspicious TSA agent, they just may be concerned about whether or not your CBD is, in fact, CBD.  To make sure that your CBD doesn’t raise any red flags, bring paperwork if you can.  The best thing is to print out the lab results regarding the CBD, so that if a TSA agent questions you, you can prove that what you have is a federally legal substance.

Tip #3: Vaping CBD on a Plane or in an Airport is a Very Bad Idea

Vaping CBD on a plane or in an airport is strictly forbidden and failing to follow this rule will likely result in a huge fine.  So, resist the urge to vape CBD before you get onto a plane, or while you’re in flight.  We know that flying can be anxiety-inducing, so if you want to have some CBD to relax before the flight, try an edible or a tincture instead.

Tip #4: Always Be Polite

TSA agents are always on the lookout for suspicious behavior, and again, this is because their job is to keep you safe.  So, while you’re traveling with CBD, make a point to avoid doing anything that can alarm the agents around you.  Basically, be polite, don’t appear agitated, follow directions and make eye contact when necessary.

Tip #5: Make Sure Your CBD Product is Clearly Labeled

If you plan on putting, say, a vape oil into a smaller bottle to make it compliant with TSA guidelines, label what it is.  This way, your TSA agent won’t have to ask you.

Traveling Can Indeed Be Stressful… 

Hence, we totally understand that having CBD by your side as you take flight can be very helpful.  Of course, when it comes to CBD, make sure that you follow all TSA guidelines so that it doesn’t get confiscated.  And, enjoy your travels!

Researchers discover two cannabis compounds ‚more potent than THC’ – The GrowthOp

Move over CBD and THC, new cannabinoids are on the way.

A study published by Nature.com has revealed the discovery of two previously unknown cannabinoids, now named THCP and CBDP. In tests on mice, researchers found that THCP demonstrated “an affinity for CB1 receptor more than thirty-fold higher compared to the one reported for THC,” making it much stronger than THC.

Although researchers have so far identified around 150 cannabinoids in cannabis, the majority of study has been focused on the two most seemingly useful — CBD and THC. THC is the component of the plant that gets users high, while CBD possesses many of the therapeutic benefits of THC without the accompanying buzz. The emergence of equally strong, or stronger, cannabinoids will no doubt lead to further study and, with luck, commercialization.

“A number of clinical trials and a growing body of literature provide real evidence of the pharmacological potential of cannabis and cannabinoids on a wide range of disorders from sleep to anxiety, multiple sclerosis, autism and neuropathic pain,” the researchers said. “In particular, being the most potent psychotropic cannabinoid, THC is the main focus of such studies.”

“THCP is endowed of an even higher binding affinity for CB1 receptor and a greater cannabimimetic activity than THC itself.”

Kevin McKernan, the chief science officer for Medicinal Genomics, amplified the study on Twitter on Monday, referring to the new cannabinoid as, “More potent than THC. Can we just grow hemp with gobs of THCP?”

The discovery of THCP might also help explain the puzzling pharmacological properties of certain cannabis strains that previously could not be attributed to the presence of THC alone, researchers said.

As for CBDP, researchers said the cannabinoid’s poor ability to bind to either CB1 or CB2 receptors does not make further exploration of its cannabimimetic activity a priority. But the opposite holds true for THCP, which researchers said holds huge potential for medicinal use.

“In our opinion, this compound should be included in the list of the main phytocannabinoids to be determined for a correct evaluation of the pharmacological effect of the cannabis extracts administered to patients.”

Want to keep up to date on what’s happening in the world of cannabis?  Subscribe to the Cannabis Post newsletter for weekly insights into the industry, what insiders will be talking about and content from across the Postmedia Network.

Researchers discover two new cannabis compounds ‚more potent than THC’ – The GrowthOp

Move over CBD and THC, new cannabinoids are on the way.

A study published by Nature.com has revealed the discovery of two previously unknown cannabinoids, now named THCP and CBDP. In tests on mice, researchers found that THCP demonstrated “an affinity for CB1 receptor more than thirty-fold higher compared to the one reported for THC,” making it much stronger than THC.

Although researchers have so far identified around 150 cannabinoids in cannabis, the majority of study has been focused on the two most seemingly useful — CBD and THC. THC is the component of the plant that gets users high, while CBD possesses many of the therapeutic benefits of THC without the accompanying buzz. The emergence of equally strong, or stronger, cannabinoids will no doubt lead to further study and, with luck, commercialization.

“A number of clinical trials and a growing body of literature provide real evidence of the pharmacological potential of cannabis and cannabinoids on a wide range of disorders from sleep to anxiety, multiple sclerosis, autism and neuropathic pain,” the researchers said. “In particular, being the most potent psychotropic cannabinoid, THC is the main focus of such studies.”

“THCP is endowed of an even higher binding affinity for CB1 receptor and a greater cannabimimetic activity than THC itself.”

Kevin McKernan, the chief science officer for Medicinal Genomics, amplified the study on Twitter on Monday, referring to the new cannabinoid as, “More potent than THC. Can we just grow hemp with gobs of THCP?”

The discovery of THCP might also help explain the puzzling pharmacological properties of certain cannabis strains that previously could not be attributed to the presence of THC alone, researchers said.

As for CBDP, researchers said the cannabinoid’s poor ability to bind to either CB1 or CB2 receptors does not make further exploration of its cannabimimetic activity a priority. But the opposite holds true for THCP, which researchers said holds huge potential for medicinal use.

“In our opinion, this compound should be included in the list of the main phytocannabinoids to be determined for a correct evaluation of the pharmacological effect of the cannabis extracts administered to patients.”

Want to keep up to date on what’s happening in the world of cannabis?  Subscribe to the Cannabis Post newsletter for weekly insights into the industry, what insiders will be talking about and content from across the Postmedia Network.

More growing pains ahead for legal cannabis market – Toronto Sun

The cannabis industry endured gruelling growing pains in 2019.

A slew of delivery, supply, and logistical issues have plagued the rollout of cannabis products across Ontario since legalization in October 2018.

More than a year after the legal market was set up, the Ontario Cannabis Retail Corp. — the Crown corporation that acts as the Ontario Cannabis Store — reported a $42-million loss when its fiscal year ended on March 31.

“As an emerging market, challenges are to be expected,” Michael Lickver, a senior vice president  with the cannabis firm Auxly, told the Toronto Sun.

The new year brings cannabis lovers across Ontario an initial offering of 59 edible, extract, and topical products that go on sale at government-sanctioned pot stores later this week.

“We have been preparing for months for this launch and have a number of procedures in place to ensure our product is available for Canadians who want to purchase,” Lickver said.

According to the OCS, the new products will range in price from $4 to $125.

Despite all the planning and preparation, OCS vice president David Lobo told reporters the initial supply of Cannabis 2.0 products will be “very limited” in variety and quantity.

Supply issues in Ontario’s legal weed market have so far been disappointing for customers and those trying to establish their products.

However, the province insists there’s a reason for optimism, noting its plans to open up the market to those wishing to open retail cannabis stores. So far, retailers wanting to open a pot store had to win a licence in a lottery.

The AGCO will begin accepting retail store applications on Jan. 6 and start issuing store authorizations on March 2 with an eye to approving 20 stores a month.

Whether the number of stores and supply is increased quickly enough to placate an already frustrated consumer base remains to be seen.

The number of weed shops operating at the end of 2020 will depend on the market.

“There’s a lot of speculation on numbers of stores. We’ve heard people say in the marketplace say anywhere from 500 to 1,500,” Lobo said. “From our perspective, we’re not going to drive that, it’s going to be the market deciding how many stores to open.”

Larger cannabis companies will likely be able to ramp up their number of storefronts the quickest, Lobo said.

Meanwhile, the price issue of legal cannabis will remain a thorn in the side of consumers who often choose to pay less on the black market.

Given the ongoing supply and price issues, it’s clear that there will be more growing pains ahead.

CDC says 55 people have died of vaping lung illness across 27 states – CNBC

A woman vapes with an electronic cigarette device.

John Keeble | Getty Images

A deadly vaping lung illness has now taken the lives of 55 people across 27 states, the Centers for Disease Control and Prevention said Tuesday.

The total number of people hospitalized with the illness so far this year now stands at 2,561 with 55 new cases diagnosed and one new fatality over 10 days, according to CDC data compiled through Friday. Patients have been found in all 50 states as well as the District of Columbia, Puerto Rico and the Virgin Islands, according to the CDC.

The CDC is tentatively calling the illness EVALI, short for e-cigarette, or vaping, product use associated lung injury. Public health officials say the main culprit is vitamin E acetate, a sticky compound found in some THC vaping products.

The CDC said in early November it was narrowing in on the substance as a „potential toxin of concern” after it was detected in 29 out of 29 lung tissue samples tested by public health officials. THC, the active ingredient in marijuana, was found in 23 of the 29 samples tested, officials said. Nicotine was detected in 16 samples, which came from 10 different states across the country.

The CDC has recommended that consumers stop vaping, particularly THC and especially anything bought off the street. Until the relationship of vitamin E acetate and lung health is better understood, it is important that the compound not be added to e-cigarette or vaping products, the CDC said.

Can I Try More CBD Products if I Already Take CBD? – The Libertarian Republic

CBD products come in a variety of forms, all tailored toward people’s individual needs. Different people use CBD for different things, and that’s reflected in the huge number of CBD products on the market. This is great because it means that no matter what your individual needs happen to be, you can find a product that’s effective for your own needs. But if you already use one method of CBD, you might find yourself wondering if you can add another method. Here’s everything you need to know about introducing more CBD products into your routine.

The Benefits of Adding a New Method of CBD

The good news is, it can be genuinely beneficial to add a new method of CBD to your CBD routine. After all, different CBD products offer different benefits, and some CBD products may have additional supplements or ingredients that can help boost the benefits you’ll already receive from the CBD itself. For example, if you love the way your CBD oil is working in the morning, but you’re having a hard time getting to sleep, you might want to add a CBD sleep gummy that will help you get ready for bed in the evening.

Is It Time to Add a New Method?

First off, it’s important to determine whether it’s a good idea to add a new method of CBD to your routine. To do that, you have to make sure that your new method of CBD would actually help. Ideally, you shouldn’t add a new method of CBD to your routine until you have a routine that’s working for you on its own. That means making sure you’re dialed in on your preferred type of CBD, so you know which areas you want to target with your new method of CBD.

Determining Which Method to Add

So, which method should you add to your CBD routine? There are lots of CBD products available on the market, and with a high-quality provider like Charlotte’s Web, you can add any of them without worrying about their quality. Check to see if the manufacturer recommends certain products for certain issues, and develop your CBD routine around those recommendations.

Taking CBD Products As Needed

Some CBD products work well as needed. For example, you may take CBD capsules or CBD gummies as needed. If you’re planning to do that, remember that you might need to change your overall dosing strategy. For example, if you currently take a dose of CBD every day, and you choose to add CBD products as needed, you might want to move down slightly on your daily dose to balance it out properly. Always adjust as you get a feel for how the products are working.

Always Make Sure Your CBD Provider Is High-Quality

Of course, the most important thing when you’re adding a new form of CBD is ensuring that the CBD you receive is top-quality. Your CBD products need to be of the highest quality so that you know they work well for you. Plus, when you get your CBD products from a reputable retailer like Charlotte’s Web, you know that you can try out any of the products in its significant catalog and you’ll get the same quality products that you’re already using.

Conclusion

It might be a great decision to add a new method of CBD to your routine. Some people benefit heavily from utilizing more than one method of CBD every day, and if you’re interested in boosting your CBD’s effectiveness, you should definitely try it out. Just remember to find a stable dose before you add another CBD product, and always get your CBD products from a top-quality retailer like Charlotte’s Web. With those two tips, you can be sure that you’re getting the most out of your CBD products every time you take them.

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Chronic use or a cannabinoid deficiency – Cannabis Hyperemesis Syndrome or THC in reverse – Cannabis Life Network

We recently proposed a theory explaining how a condition that induces intense pain and profuse vomiting after chronic use of cannabis, known as Cannabis Hyperemesis Syndrome (CHS), might function. Typically stories fluctuate in the realm of Refer Madness when they describe it as a “symptom” of THC itself. Many seem to think cannabinoids are the cause, a link since chronic consumers are the only ones who experience the condition. Yet, it is highly unlikely cannabis directly caused the condition; not if any victims did continue to subsequently use any kind of cannabis without ill effect, as was reported. Chronic use may still be related through through an association with a specific degenerative condition though.

What changes occur from cannabis use that can be linked to CHS,? Do any even make sense?

Chronic THC use – losses and gains

THC

Chronic THC consumption does cause a tolerance to its effect, albeit temporary. This is typically the brain adjusting to THC-induced activity in the CB1 receptor; the infamous target of intoxication that is also indirectly associated with undisputed therapeutic potential. Tolerance essentially acts as a homeostatic gyroscope, keeping the activity of the cannabinoid system in check. However, the brain also adapts to large, continual doses of THC with a beautiful morphology of certain cells and synapses.

One change is in immune cells known as glial cells, which develop additional CB2 receptors during heavy cannabis use. These purely non-intoxicating cannabinoid receptors are known to predominantly support immune functions in the body, but also regulate neurological effects in the brain. Chronic cannabis users are unique due to their increased sensitivity to CB2 receptor agonists, like THC or the terpene, caryophyllene.

It is true that tolerance to THC will result in a loss of its intoxicating potency. At the same though, chronic use leads to a more calm, therapeutic effect due to these new microglial-bound CB2 receptors.

How exactly can the balance of cannabinoid receptors become upset?

Slipping through neuroprotection – losing cells

People can carry dormant genetic alterations that lead to autoimmune and neurodegenerative diseases later in life, or after an episode of trauma. Generally speaking, this is not unusual, but specific variations and characteristics can be. Certain deficiencies in cannabinoid receptors themselves are not uncommon, either.

A chronic cannabis user with an unrelated degradation of glial cells in specific regions of the brain would ultimately lose their new CB2 receptors. Their homeostatic gyroscope would be thrown off, potentially leading to unique symptoms. Fortunately, though, that imbalance should not cause negative symptoms from THC, at least not those of CHS. Even if that degradation occurs in specific regions of the brain, such as the Chemoreceptor Trigger Zone (CTZ) and the ‘vomit center,’

Cannabinoid receptor deficiencies

There however does exist a rare CB1 receptor deficiency that can cause the body to respond to THC with reverse effects, as previously reported. A normal tone of CB2 receptors might protect the switch that flips THC’s effects in those unique circumstances. If CB2 receptors were lost due to an unrelated glial cell malfunction or degradation the trigger could become unblocked and flip, causing the symptoms of CHS.

Flipping the switch on THC

That “switch” has a few positions and can be triggered by CBD, but also by neurotransmitters like dopamine. Caryophyllene will not affect CB1 receptors directly but does have a peripheral effect by inhibiting dopamine through CB2 receptor agonism. This is how the terpene caryophyllene is capable of indirectly switching a deficient CB1 receptor back to normal.

For this effect to occur though, the CB1 receptor would also have to tightly co-express dopamine, which does happen, except that too is uncommon.

When a string of rare signalling deficits in the cannabinoid system aligns like lock pins by degraded glial cells, it is not necessarily caused by cannabis use. Yet, it will still affect chronic users in a profound, unique way. Furthermore, the condition can only subside on its own once the body is given time to readjust it’s own endogenous cannabimimetic gyroscope, not once THC leaves the system. This is supported by those empiriological cases of continued use.

Vomit and chemoreceptors

Hyperemesis

Vomiting and nausea are caused by many different internal dysfunctions that range from within the gut to the deep inside brain. Cannabinoid receptors are located in most of these, including the ‘vomit center.’ Endocannabinoid system (ECs) activation acutely prevents emesis caused by the guts nervous system, similar to how it prevents migraines by suppressing hyperactive nerves in the face. An episode of powerful vomiting and discomfort would occur if the effects of the ECs were reversed in the Chemoreceptor Trigger Zone or Vagus nerve. In particular, if the inhibitory effect on several vomit-inducing transmitters such as dopamine, ACH, PKA, and 5HT3a were to flip their function.

Can the loss of CB2 receptors truly enable the renewal of a dormant relationship between CB1 receptors and dopamine, and is that renewal actually able to modulate CB1 receptors?

Unfortunately, the concept is nothing more than a hypothesis at this point. While the theory can be tested and proven, or otherwise, CHS certainly has other potential causes. A deficiency in the cannabinoid system that causes it to contort into an antagonist of itself appears to be one necessary piece of the puzzle. In another idea, it is the entire image.

Stay tuned to find out how immune disorders like thyroid and celiac are related to deficiencies in the CB2 receptor itself. Much like migraine, fibromyalgia, and IBD are related to CB1 receptor deficiencies. How are wheat and spicy peppers similar to each other, as well as other selective effects of THC in reverse?

Photo courtesy of Sciencemag

Sources

Hoffman AF, Lupica CR. Synaptic targets of Δ9-tetrahydrocannabinol in the central nervous system. Cold Spring Harb Perspect Med. 2013;3(8):a012237. Published 2013 Aug 1. doi:10.1101/cshperspect.a012237

Ibsen MS, Connor M, Glass M. Cannabinoid CB and CB Receptor Signaling and Bias. Cannabis Cannabinoid Res. 2017;2(1):48-60.

Russo EB. Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes. Cannabis Cannabinoid Res. 2016;1(1):154–165. Published 2016 Jul 1. doi:10.1089/can.2016.0009

Stella N. Chronic THC intake modifies fundamental cerebellar functions. J Clin Invest. 2013;123(8):3208–3210. doi:10.1172/JCI70226

Reakiro Europe to Promote High-Quality CBD Products to the American Consumer – GlobeNewswire

BOCA RATON, FL, Dec. 31, 2019 (GLOBE NEWSWIRE) — Reakiro Europe’s dedication to the highest-quality CBD products is its core mission.Reakiro accomplishes this goal by controlling 100 percent of all stages of production from farming to extraction to packaging.“We are a ‘seed to sale’ manufacturer. We control the entire manufacturing process from choosing the seeds to packaging,” said Sam Kearley, head of sales for Reakiro Europe. “Our company’s mission is to create, develop, and supply the highest quality hemp-based products for our valued customers.”The valued customers Kearley refers to will soon include the American consumer. Reakiro plans to bring its high-quality CBD oils, sprays, capsules and, skincare products to the U.S. market in 2020.Kearley said the company started in 2016 with four entrepreneurial business professionals who foresaw the growth of the CBD industry. “We decided back then that we wanted to be the number one manufacturer and supplier of full-spectrum cannabinoid oils and hemp-based products.”Reakiro’s main competitive advantage is its “seed to sale” business model.Kearley said only a manufacturer who controls the entire process from seed to sale could guarantee the highest quality CBD products.“We have to consider the entire process. We select the best flower strains which are grown only in Europe’s most favorable climates,” Kearley said, adding that in manufacturing Reakiro only uses ethanol-based extraction and refinement.“Because of our entire process, we produce the finest and purest CBD oil in the world,” he said. “To guarantee the quality of the products, we have in-house and third-party testing,” he added.Reakiro will introduce four CBD supplements and three skin and body care products to the U.S. markets:Full Spectrum, 5% CBD OilFull Spectrum, 15% CBD OilFull Spectrum CBD Spray with PeppermintCBD Capsules with Black Pepper ExtractGoddess Sativa Nourishing Night CreamGoddess Sativa Body ButterGoddess Sativa Muscle Relief Cooling GelFor more information, check out Reakiro’s CBD products at cbdreakiro.com.AttachmentsCBD 60_Capsules_PiperineBodyButter_Vanilla&MilkCreamAndrew Polin
Reakiro Europe, Ltd
561-544-0719
apolin@inhealthmedia.com